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VemoHerb Guggulsterone (90 caps)

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Helps the body to keep normal metabolism in a natural way even during dieting*
Supports fat loss*
Considered as one of the safest available weight loss supplements on the market*

Supports the metabolism and fat burning process naturally. *

Dietary supplement, based on dry extract from Commiphora mukul (Guggul) standardized at 35 mg Guggulsteroids and 35 mg Е&Z Guggulsterones.

Guggulsterones are plant steroids, which are found in the resin of the plant Commiphora mukul (common also as Guggul). This powerful ancient herb has recently been re-discovered by the nowadays modern Western culture.

How and Why It Works?

Guggulsterones have been used for thousands of years to help maintain normal metabolism, and to support fat loss and normal cholesterol levels, without side effects.* [1-3]

Scientific studies indicate that Guggulsterones support the reduction of bodyweight and this is mostly attributed to the positive effect which they have on the normal function of thyroid gland, responsible for controlling the metabolic rate.* [4] When the hormone levels of the thyroid increase, the metabolic rate is boosted, and vice versa. Following that mechanism, when a caloric restriction is present due to a lower food intake (as it occurs during weight loss diets), the defensive reaction of the body is to decrease the metabolism rate by lowering the thyroid hormone levels. It is a well-known fact that when you eat less than you need for basic biological function, your body slows down your metabolism in order to keep its reserves for longer time. For example, you normally need 2000 kcal per day, but once you start diet you take 1000 kcal in order to lose weight. However, your clever organism compensates that scarcity and as the metabolism is slowed down, your body is now satisfied with 1000 kcal (and not with 2000 kcal). That means once you start eating normally (2000 kcal) it is already too much for your organism, and it quickly gains back the weight you lost during the diet. [5] In such cases during diets, the role of VemoHerb® Guggulsterone is to ensure that the metabolism stays at normal levels, despite the calorie decrease.* [6] Hence, they promote the weight loss program for the maximum desirable effect.* This is the most healthy and safe way to lose weight.*

Some studies also suggest that Guggulsterones help in maintaining the normal balance of HDL (good cholesterol) and LDL (bad cholesterol), adding extra benefits to the magnificent properties of this incredible herb.* [1, 3, 7]

Recommended for:

Guggulsterones are a perfect supplement for anyone who is looking for a safe and effective way of supporting the weight loss process, especially in cases of prolonged dieting.* [8, 9, 10, 11] Guggulsterones do not affect negatively the normal functions of the central nervous and the cardiovascular systems, and some studies suggest that they can support them.* [12, 13] Thus, they are generally considered as one of the safest available weight loss supplements on the market.* [9, 14] Guggulsterones influence positively the thyroid gland’s activity, and in that way assist the regulation of the metabolic rate in a natural way.* They support the weight loss rate, since more calories are burned by the body everyday.* [6, 8-11]

VemoHerb® Guggulsterone is based on one of the most potent natural Guggul extracts available today, thus ensuring the premium quality of the product and the cutting edge results of our customers.

The pack contains

90 vegan capsules

Active substances in one capsule

350 mg dry extract from Commiphora mukul (Guggul) standardized at 35 mg Guggulsteroids and 35 mg Е&Z Guggulsterones

Recommended daily dose

1 – 2 capsules, 3 times a day

Directions for use

Take the capsule between the meals or as directed on the label

The product is a food supplement not a medical drug. The product is not a substitute for a varied diet. Do not exceed the recommended daily dose. It is not recommended for pregnant, nursing women and children! Not recommended for people who have functional problems with their thyroid gland.

Some scientific evidence suggests

Other scientific studies suggest that Commiphora mukul extract is one effective tool for weight loss, when applied along with low calorie diets. [6, 8, 9, 10, 11] Guggulsterones have been reported to have inhibiting effect on fat cells and assist the regulated fats accumulation. [11, 15]

Other scientific studies [16 – 21]

These evidences are limited and not conclusive.

 

References

1. Yu BZ, Kaimal R, Bai S, El Sayed KA, Tatulian SA, Apitz RJ, Jain MK, Deng R, Berg OG – Effect of guggulsterone and cembranoids of Commiphora mukul on pancreatic phospholipase A(2): role in hypocholesterolemia.

2. Yamada T, Sugimoto K – Guggulsterone and Its Role in Chronic Diseases.

3. Das S, Datta A, Bagchi C, Chakraborty S, Mitra A, Tripathi SK – A Comparative Study of Lipid-Lowering Effects of Guggul and Atorvastatin Monotherapy in Comparison to Their Combination in High Cholesterol Diet-Induced Hyperlipidemia in Rabbits.

4. Tripathi YB, Malhotra OP, Tripathi SN. – Thyroid Stimulating Action of Z-Guggulsterone Obtained from Commiphora mukul.

5. Katzeff HL, Selgrad C. – Maintenance of thyroid hormone production during exercise-induced weight loss.

6. Panda S, Kar A. – Guggulu (Commiphora mukul) potentially ameliorates hypothyroidism in female mice.

7. Mithila MV, Khanum F. – The appetite regulatory effect of guggulsterones in rats: a repertoire of plasma hormones and neurotransmitters.

8. Bhatt AD, Dalal DG, Shah SJ, Joshi BA, Gajjar MN, Vaidya RA, Vaidya AB, Antarkar DS. – Conceptual and methodologic challenges of assessing the short-term efficacy of Guggulu in obesity: data emergent from a naturalistic clinical trial.

9. Jose Antonio, Carlon M.Colker, Georgeann, C.Torina, QuihuShi, WilliamBrink, Douglas Kaiman – Effects of a standardized guggulsterone phosphate supplement on body composition in overweight adults.

The purpose of this study was to determine the effects of a guggulsterone phosphate salt compound on body composition and mood states in overweight adults. In a double-masked, randomized, placebo-controlled study, 20 subjects with a body-mass index >25 kg/m2 were separated into 1 of 3 groups. The experimental group received guggulsterones 750 mg and phosphate 1650 mg daily, the placebo group received maltodextrin capsules, and the control group received no treatment for 6 weeks. Subjects were instructed to follow the American Heart Association Step One diet and a 3-day-per-week circuit exercise program. Body weight decreased significantly in the experimental group (3.2%, P < 0.05) and fat mass decreased significantly in the experimental (20.6%) and control (8.6%) groups (P < 0.01). However, between-group differences in weight loss were not statistically significant. Profile of Mood States (POMS)-fatigue decreased significantly in the experimental group (63.7%, P< 0.01), whereas POMS-vigor increased significantly in the experimental group (32.3%, P < 0.01) and decreased significantly in the placebo group (15.6%, P < 0.01). Results of this study suggest that ingestion of a guggulsterone phosphate salt compound concurrent with regular exercise will result in a significant loss of body weight and improved mood states.

10. Sharma B, Salunke R, Srivastava S, Majumder C, Roy P. – Effects of guggulsterone isolated from Commiphora mukul in high fat diet induced diabetic rats.

11. Rayalam S, Yang JY, Della-Fera MA, Park HJ, Ambati S, Baile CA. – Anti-obesity effects of xanthohumol plus guggulsterone in 3T3-L1 adipocytes.

12. Ojha SK, Nandave M, Arora S, Mehra RD, Joshi S, Narang R, Arya DS. – Effect of Commiphora mukul extract on cardiac dysfunction and ventricular function in isoproterenol-induced myocardial infarction.

13. Shen T, Li GH, Wang XN, Lou HX. – The genus Commiphora: a review of its traditional uses, phytochemistry and pharmacology.

14. Jeong-Yeh Yang, Mary Anne Della-Fera and Clifton A. Baile – Guggulsterone inhibits adipocyte differentiation and induces apoptosis in 3T3-L1 cells.

15. Thappa DM, Dogra J. – Nodulocystic acne: oral gugulipid versus tetracycline.

16. Ajaz A. Bhat, Kirti S. Prabhu, Shilpa Kuttikrishnan, Roopesh Krishnankutty, Jayaprakash Babu,Ramzi M. Mohammad, and Shahab Uddin – Potential therapeutic targets of Guggulsterone in cancer

17. Shen T, Zhang L, Wang YY, Fan PH, Wang XN, Lin ZM, Lou HX. – Steroids from Commiphora mukul display antiproliferative effect against human prostate cancer PC3 cells via induction of apoptosis.

18. Guoqin Jiang, Xiao Xiao, Yan Zeng, Kalyanam Nagabhushanam, Muhammed Majeed and Dong Xiao – Targeting beta-catenin signaling to induce apoptosis in human breast cancer cells by z-guggulsterone and Gugulipid extract of Ayurvedic medicine plant Commiphora mukul.

19. Dong Xiao and Shivendra V. Singh – z-Guggulsterone, a constituent of Ayurvedic medicinal plant Commiphora mukul, inhibits angiogenesis in vitro and in vivo.

20. Xu HB, Xu LZ, Mao XP, Fu J. – Guggulsterone of Commiphora mukul resin reverses drug resistance in imatinib-resistant leukemic cells by inhibiting cyclooxygenase-2 and P-glycoprotein.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

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VemoHerb Guggulsterone (90 caps)

VemoHerb Guggulsterone (90 caps)

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